Synthesis and application of nanometer hydroxyapatite in biomedicine

Abstract Nano-hydroxyapatite (nano-HA) has been widely studied as a promising biomaterial because of its potential mechanical and biological properties. In this article, different synthesis methods for nano-HA were summarized. Key factors the nano-HA, including reactant concentration, effects temperature, PH, additives, aging time, sintering, separately investigated. The performances depend strongly on structures, morphology, crystallite sizes. Nano-HA with morphologies may cause effects, such protein adsorption, cell viability proliferation, angiogenesis, vascularization. Recent research progress respect to functions in some specific applications are summarized future development nano-sized hydroxyapatite is prospected.